Public trust and genomic medicine in Canada and the UK.

Background: Genomic medicine could improve precise risk stratification, early prevention, and personalised treatment across a broad spectrum of disease. As this reality approaches, questions on the importance of public trust arise. The success of genomic medicine initiatives is influenced by the public's trust and willingness to engage. Specific social actors influential in the public's trust have been identified by the "Your DNA, Your Say" study, including doctors, researchers, and governments. This paper aims to identify and examine which specific social actors, if any, in Canada and the United Kingdom (UK) are the most trustworthy and influential to engage the public in genomic medicine research. Methods: Using data from the 'Your DNA, Your Say' study, logistic regression models and Pearson's chi-square tests were conducted to explore trust in social actors across Canada and the UK. Results: The results demonstrate Canada and the UK significantly differ in public trust and willingness to donate. Non-profit researchers, domestic doctors, and personal doctors were identified to be the most influential and trustworthy social actors in Canada and the UK. Conclusions: The comparative results indicate that both countries would benefit from engaging the public through doctors and non-profit researchers. The UK could additionally support public trust by engaging with the public through the National Health Service. However, the results suggest that whilst public trust is significant, it may be neither necessary nor sufficient in influencing willingness to donate. Future research could do well to investigate how the importance of public trust compares in countries with lower public trust

Radio Emission from the Composite Supernova Remnant G326.3-1.8 (MSH15-56)

High resolution radio observations of the composite supernova remnant (SNR) G326.3-1.8 or MSH 15-56 with the Australia Telescope Compact Array show details of both the shell and the bright plerion which is offset about 1/3 of the distance from the center of the SNR to the shell. The shell appears to be composed of thin filaments, typical of older shell SNRs. The central part of the elongated plerion is composed of a bundle of parallel ridges which bulge out at the ends and form a distinct ring structure on the northwestern end. The magnetic field with a strength of order 45 microGauss, is directed along the axis of the ridges but circles around the northwestern ring. This plerion is large and bright in the radio but is not detected in x-ray or optical wavelengths. There is, however, a faint hard x-ray feature closer to the shell outside the plerion. Perhaps if the supernova explosion left a rapidly moving magnetar with large energy input but initially rapid decay of both relativistic particles and magnetic field, the observed differences with wavelength could be explained.Comment: 15 pages, 10 figures, accepted by Ap

On Sylvia Bowerbank, Green Literary Scholar

To accompany the posthumous publication of Sylvia Bowerbank’s personal essay “Sitting in the Bush, Or Deliberate Idleness,” eight scholars introduce her ecocritical thought and practice to a new generation of ecocritics by reflecting on the ways Sylvia herself or her writing or teaching influenced them. Their tributes to this trailblazing ecocritic emphasize her passionate commitment to radical green change within the world, within the university, and within the self

The rare and the common: scale and the genetic imaginary in Alzheimer's disease drug development.

In this paper I examine how the promissory value of genetics is constituted through processes of scale and scaling, focussing on the relationship between "rare" and "common" forms of disease. I highlight the bodies and spaces involved in the production of post-genomic knowledge and technologies of Alzheimer's disease and the development of new disease-modifying drugs. I focus on the example of the development of a monoclonal antibody therapy for Alzheimer's disease. I argue that the process of therapeutic innovation, from genetic studies and animal models to phase III clinical trials, reflects the persistent importance of a genetic imaginary and a mutually constitutive relationship between the rare and the common in in shaping visions of Alzheimer's disease medicine. Approaching this relationship as a question of scale, I suggest the importance of attending to how and where genomic knowledge is "scaled" or proves resistant to scaling.Research contributing to this paper was funded through the ethical, legal and social implications workpackage of the IMI European Prevention of Alzheimer's Dementia project

Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep

Chronic lipopolysaccharide (LPS) exposure may contribute to the pathogenesis of a number of lung diseases including COPD and emphysema. We sought to develop a large- animal model of emphysema using repeated LPS administration into sheep lung segments. An experimental protocol was designed to facilitate comparisons with elastase-treated and control segments within the same lung of individual sheep. Histopathologic evaluation of segments treated with LPS demonstrated low-grade inflammation characterized by an increase in the number of intra-alveolar macrophages and lymphocytes. Treated segments demonstrated a significant reduction in airspace surface area (ASA), an increase in percent disrupted alveolar attachments and the distance between normal alveolar attachments, and a reduction in the number of normal alveolar attachments surrounding nonrespiratory bronchioles. Coefficient of variation of individual ASA measurements in elastase-treated segments was indicative of a heterogeneous parenchymal response, in contrast to that associated with chronic LPS treatment. Our results demonstrate that chronic LPS treatment of individual lung segments in sheep induces microscopic emphysema qualitatively and quantitatively consistent with both accepted pathologic definitions of this condition and with that produced by airway instillation of elastolytic enzymes. Development of this phenotype is associated with evidence of downregulated activation of transforming growth factor beta

Ultraviolet Observations of Super-Chandrasekhar Mass Type Ia Supernova Candidates with Swift UVOT

Among Type Ia supernovae (SNe~Ia) exist a class of overluminous objects whose ejecta mass is inferred to be larger than the canonical Chandrasekhar mass. We present and discuss the UV/optical photometric light curves, colors, absolute magnitudes, and spectra of three candidate Super-Chandrasekhar mass SNe--2009dc, 2011aa, and 2012dn--observed with the Swift Ultraviolet/Optical Telescope. The light curves are at the broad end for SNe Ia, with the light curves of SN~2011aa being amongst the broadest ever observed. We find all three to have very blue colors which may provide a means of excluding these overluminous SNe from cosmological analysis, though there is some overlap with the bluest of "normal" SNe Ia. All three are overluminous in their UV absolute magnitudes compared to normal and broad SNe Ia, but SNe 2011aa and 2012dn are not optically overluminous compared to normal SNe Ia. The integrated luminosity curves of SNe 2011aa and 2012dn in the UVOT range (1600-6000 Angstroms) are only half as bright as SN~2009dc, implying a smaller 56Ni yield. While not enough to strongly affect the bolometric flux, the early time mid-UV flux makes a significant contribution at early times. The strong spectral features in the mid-UV spectra of SNe 2009dc and 2012dn suggest a higher temperature and lower opacity to be the cause of the UV excess rather than a hot, smooth blackbody from shock interaction. Further work is needed to determine the ejecta and 56Ni masses of SNe 2011aa and 2012dn and fully explain their high UV luminosities.Comment: 12 pages, 8 figures Accepted for publication in the Astrophysical Journal Data available on the Swift supernova website http://swift.gsfc.nasa.gov/docs/swift/sne/swift_sn.htm

Spatial and temporal stability of weed patches in cereal fields under direct drilling and harrow tillage

The adoption of conservation agriculture (CA) techniques by farmers is changing the dynamics of weed communities in cereal fields and so potentially their spatial distribution. These changes can challenge the use of site-specific weed control, which is based on the accurate location of weed patches for spraying. We studied the effect of two types of CA (direct drilling and harrow-tilled to 20 cm) on weed patches in a three-year survey in four direct-drilled and three harrow-tilled commercial fields in Catalonia (North-eastern Spain). The area of the ground covered by weeds (hereafter called “weed cover”) was estimated at 96 to 122 points measured in each year in each field, in 50 cm × 50 cm quadrats placed in a 10 m × 10 m grid in spring. Bromus diandrus, Lolium rigidum, and Papaver rhoeas were the main weed species. The weed cover and degree of aggregation for all species varied both between and within fields, regardless of the kind of tillage. Under both forms of soil management all three were aggregated in elongated patterns in the direction of traffic. Bromus was generally more aggregated than Lolium, and both were more aggregated than Papaver. Patches were stable over time for only two harrow-tilled fields with Lolium and one direct-drilled field with Bromus, but not in the other fields. Spatial stability of the weeds was more pronounced in the direction of traffic. Herbicide applications, crop rotation, and traffic seem to affect weed populations strongly within fields, regardless of the soil management. We conclude that site-specific herbicides can be applied to control these species because they are aggregated, although the patches would have to be identified afresh in each season.This research was funded by the Spanish National Program (project: AGL2010-22084-C02-0). A.E.M. was funded by the Institute Strategic Programme (ISP) grants, “Soils to Nutrition” (S2N) grant number BBS/E/C/000I0330, and the joint Natural Environment Research Council (NERC) and Biotechnology and Biological Sciences Research Council (BBSRC) ISP grant “Achieving Sustainable Agricultural Systems” (ASSIST) grant number BBS/E/C/000I0100, using facilities funded by the BBSRC